期刊
WORLD JOURNAL OF CLINICAL CASES
卷 3, 期 4, 页码 345-352出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.12998/wjcc.v3.i4.345
关键词
Atherosclerosis; Inflammatory cytokines; Pro-inflammatory mediators; Immune cells; Adhesion molecules
Atherosclerosis is a chronic inflammatory disease arising from lipids, specifically low-density lipoproteins, and leukocytes. Following the activation of endothelium with the expression of adhesion molecules and monocytes, inflammatory cytokines from macrophages, and plasmacytoid dendritic cells, high levels of interferon (IFN)-alpha and beta are generated upon the activation of toll-like receptor-9, and T-cells, especially the ones with Th1 profile, produce pro-inflammatory mediators such as IFN-gamma and upregulate macrophages to adhere to the endothelium and migrate into the intima. This review presents an exhaustive account for the role of immune cells in the atherosclerosis.
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