期刊
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
卷 48, 期 1, 页码 165-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.gtc.2018.09.012
关键词
Wheat; Systemic immune activation; Intestinal barrier function; Gluten; Amylase/protease inhibitor; Fructan; Biomarkers; Antibody to native gliadin
资金
- National Center for Advancing Translational Sciences, NIH [UL1 TR000040]
Non-celiac wheat sensitivity (NCWS) is characterized by gastrointestinal and extra-intestinal symptoms following the ingestion of gluten-containing cereals in subjects without celiac disease or wheat allergy. The identity of the molecular triggers in these cereals responsible for the symptoms of NCWS remains to be delineated. Recent research has identified a biological basis for the condition, with the observation of systemic immune activation in response to microbial translocation that appears to be linked to intestinal barrier defects. Ongoing research efforts are aimed at further characterizing the etiology, mechanism, and biomarkers of the condition.
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