期刊
FUTURE MEDICINAL CHEMISTRY
卷 10, 期 23, 页码 2745-2761出版社
FUTURE SCI LTD
DOI: 10.4155/fmc-2018-0346
关键词
anemia; fluorogenic substrates; hepcidin; iron overload; matriptase-2; peptide inhibitors; serine proteases
资金
- National Science Centre in Poland [UMO-2014/13/N/ST5/01299]
Matriptase-2 (MT2) is a membrane-anchored proteolytic enzyme. It acts as the proteolytic key regulator in human iron homeostasis. A high expression level can lead to iron overload diseases, whereas mutations in the gene encoding MT2, TMPRSS6, may result in various forms of iron deficiency anemia. Recently, MT2 has been reported as a positive prognostic factor in breast and prostate cancers. However, the exact functions of MT2 in various pathophysiological conditions are still not fully understood. In this review, we describe the synthetic tools designed and synthesized to regulate or monitor MT2 proteolytic activity and present the latest knowledge about the role of MT2 in iron homeostasis and cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据