期刊
FOOD CHEMISTRY
卷 271, 期 -, 页码 707-714出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2018.07.216
关键词
beta-Carotene; alpha-Lactalbumin; Self-assembled alpha-lactalbumin micelles; Anti-oxidant activity
资金
- National Natural Science Foundation of China [NSFC 31471577, 31772014]
- Beijing Nova Program [Z181100006218071]
The low aqueous solubility, stability and bioavailability of hydrophobic bioactive compounds, such as beta-carotene (beta-c), greatly hinder their application in foods. Nanocarriers could overcome this problem by facilitating the delivery of the functional ingredients. We prepared lactalbumin (alpha-lac) micelles by partial enzymatic hydrolysis in aqueous solution. beta-c can be incorporated into the cores of these micelles via hydrophobic interactions. The aqueous solubility and stability under 60 degrees C heating or UV light irradiation of encapsulated beta-c improved significantly compared with free beta-c. Moreover, it had an increased cellular uptake (3 times) and transmembrane permeability (13 times) in a Caco-2 cell monolayer model. It suggested that alpha-lac micelle-encapsulated beta-c had an enhanced cellular absorption and transport efficiency. Encapsulated beta-c also exhibited an enhanced cellular anti-oxidant activity (CAA) compared with free beta-c. This work demonstrates that alpha-lac micelles showed a great potential for delivery of hydrophobic bioactive compounds in foods.
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