期刊
FERTILITY AND STERILITY
卷 110, 期 7, 页码 1328-1337出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2018.08.022
关键词
Alcohol; body mass index; ectopic pregnancy; smoking; tubal pregnancy
资金
- National Institute of Health from the National Cancer Institute [UM1CA17672]
- Eunice Kennedy Shriver National Institute for Child Health and Human Development [L50HD085359]
- National Institute of Environmental Health Sciences [K99ES026648]
Objective: To evaluate the relationship between demographic, lifestyle, and reproductive factors and the risk of ectopic pregnancy (EP). Design: Prospective cohort. Setting: United States. Patient(s): Nurses' Health Study II cohort comprising 41,440 pregnancies from 22,356 women. Intervention(s): Demographic, lifestyle, and reproductive factors self-reported in 1989 then updated every 2 years. Multivariable log-binomial regression models with generalized estimating equations were used to estimate adjusted risk ratios (aRR). Main Outcome Measure(s): Ectopic pregnancy. Result(s): Incident EP was reported in 411 (1.0%) pregnancies. Former and current smokers had 1.22 (95% confidence interval [CI], 0.97-1.55) and 1.73 (95% CI, 1.28-2.32) times, respectively, the risk of EP compared with never smokers. The risk of EP 10 years after quitting was similar to never smokers (aRR 0.90; 95% CI, 0.60-1.33). Women consuming >= 10 g/day of alcohol had 1.50 (95% CI, 1.08-2.09) times the risk of EP compared with never consumers. In utero exposure to diethylstilbestrol (aRR 3.55; 95% CI, 2.51-5.01), earlier initiation of oral contraceptives (aRR 2.64; 95% CI, 1.70-4.09 for <16 years vs. never), intrauterine device use (aRR 3.99; 95% CI, 2.06-7.72), or history of infertility (aRR 3.03; 95% CI, 2.48-3.71) or tubal ligation (aRR 16.27; 95% CI, 11.76-22.53) also were associated with a higher risk of EP. Conclusion(s): Women who were current or former smokers, consumed >= 10 g/day of alcohol, were exposed to diethylstilbestrol in utero, initiated oral contraceptives at earlier than age 16 years (which may be a marker of riskier sexual behaviors), and who had a history of infertility, intrauterine device use, or tubal ligation had a higher risk of EP. (C) 2018 by American Society for Reproductive Medicine. El resumen esta disponible en Espanol al final del articulo.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据