期刊
FEBS LETTERS
卷 593, 期 2, 页码 219-229出版社
WILEY
DOI: 10.1002/1873-3468.13302
关键词
Deinococcus radiodurans R1; DR0846; molecular chaperone; peroxidase; peroxiredoxin Q
资金
- Nuclear R&D Program of the Ministry of Science and ICT (MSIT), Republic of Korea
Deinococcus radiodurans R1 is extremely resistant to ionizing radiation and oxidative stress. In this study, we characterized DR0846, a candidate peroxiredoxin in D. radiodurans. DR0846 is a peroxiredoxin Q containing two conserved cysteine residues. DR0846 exists mainly in monomeric form with an intramolecular disulfide bond between the two cysteine residues. We found that DR0846 functions as a molecular chaperone as well as a peroxidase. A mutational analysis indicates that the two cysteine residues are essential for enzymatic activity. A double-deletion mutant lacking DR0846 and catalase DR1998 exhibits decreased oxidative and heat shock stress tolerance with respect to the single mutants or the wild-type cells. These results suggest that DR0846 contributes to resistance against oxidative and heat stresses in D. radiodurans.
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