期刊
FASEB JOURNAL
卷 33, 期 4, 页码 5237-5247出版社
WILEY
DOI: 10.1096/fj.201802040R
关键词
osteoblasts retinoids; physical activity; Raman spectroscopy
资金
- Marie Curie Initial Training Network (FP7-People-2013-ITN) [607446]
- Swedish Research Council
- Swedish government [237551]
- Swedish county councils [237551]
- IngaBritt and Arne Lundberg Foundation
- Royal 80 Year Fund of King Gustav V
- Ake Wibergs Foundation
Increased vitamin A consumption is associated with decreased cortical bone mass and increased fracture risk in humans. Rodent studies have demonstrated that hypervitaminosis A increases cortical bone resorption, whereas the importance of the effects on bone formation is less well defined. We used an experimental model of increased bone formation by loading of the tibiae to investigate the effect of vitamin A on bone formation. Control [retinol activity equivalents (RAE) 4.5 mu g/g chow] or vitamin A (RAE 60 mu g/g chow) diets were given to female C57BL/6N mice for 4 wk, after which the tibiae were subjected to axial loading on alternate days for 2 wk, while the diets were continued. Vitamin A inhibited the loading-induced increase in trabecular and cortical bone volume. This was attributed to inhibition of loading-induced increase in osteoblast number and activity, and expression of osteoblastic genes Sp7, Alpl, and Col1a1 in cortical bone. Vitamin A, loading, and combination thereof also resulted in site-specific effects on bone composition measured by Raman spectroscopy. In summary, a clinically relevant dose of vitamin A suppresses the loading-induced gain of bone mass by decreasing bone formation. These observations may have implications for regulation of bone mass caused by physical activity and the risk of osteoporosis in humans.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据