期刊
EXPERT OPINION ON THERAPEUTIC TARGETS
卷 23, 期 1, 页码 21-28出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14728222.2019.1550074
关键词
Neuroplasticity; neurostimulation; TMS; paired associative stimulation; prefrontal cortex; gamma oscillations; theta-gamma coupling; tACS; tDCS
资金
- Brain Canada
- Brain and Behavior Research Foundation
- CAMH Foundation
- Canadian Institutes of Health Research (CIHR)
- Ontario Ministry of Health and Long-Term Care
- US National Institute of Health (NIH)
- Weston Brain Institute
- Canada Foundation for Innovation
- Canada Research Chair
- Ontario Ministry of Research and Innovation
Introduction: In 2017, it was estimated that close to 50 million people were living with dementia worldwide and this number is expected to double every 20 years. No effective treatment exists yet probably because by the time Alzheimer's dementia (AD) has developed it is too late to intervene. Areas covered: Mild cognitive impairment (MCI) is a clinical state that typically precedes AD. In MCI, the prefrontal cortex supports compensatory mechanisms that depend on robust synaptic plasticity and that delay progression to AD. This review focuses on novel neurostimulation approaches that could enhance prefrontal cortical plasticity in vivo by enhancing prefrontal cortical plasticity and function in patients with MCI or AD. It also describes novel neurophysiological markers that could function as targets for such approaches. Expert commentary: Targeting synaptic plasticity in patients with early AD or at risk of developing AD could be a promising approach to slow progression or prevent AD.
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