期刊
EXPERT OPINION ON DRUG DISCOVERY
卷 14, 期 1, 页码 81-89出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/17460441.2019.1546691
关键词
Animal models; antidepressant drugs; clinical trials; cognition; major depressive disorder; serotonin receptors; serotonin transporters
资金
- New National Excellence Program of the Ministry of Human Capacities, of the Government of Hungary [UNKP-18-4-SE-33]
- Janos Bolyai Research Fellowship Program of the Hungarian Academy of Sciences
Introduction: Vortioxetine is a novel antidepressant drug approved for the treatment of major depressive disorder (MDD) in adults. It is formulated into tablets and has a dose range of 5-20 mg. The recommended starting dose is 10 mg administered orally once daily without the need for food. Areas covered: This review focuses on the preclinical and clinical discovery of vortioxetine. It analyzes the pharmacological, neurochemical, and behavioral mechanisms of the medication and how these contribute to its potential therapeutic advantages as described in published preclinical and clinical studies and product labels. Expert opinion: Vortioxetine displays high affinity for serotonin transporter (SERT), and serotonin 5-HT3, 5HT(1A), 5HT(7) receptors. Functional studies show that vortioxetine acts as a SERT blocker, a 5-HT3, 5-HT7 receptor antagonist, and a 5-HT1A receptor agonist. The drug is active in animal models predictive of antipsychotic and antidepressant activities and demonstrates procognitive effects in several animal models that assessed memory, cognition, and executive functions. Short- and long-term clinical trials demonstrated the clinical efficacy of vortioxetine in treating depressive symptoms and cognitive deficits in MDD patients. It also displays fairly benign safety and tolerability profiles. Vortioxetine's unique psychopharmacological properties might contribute to an improved clinical outcome in MDD patient populations.
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