期刊
CURRENT MOLECULAR PHARMACOLOGY
卷 8, 期 2, 页码 206-222出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1874467208666150507105105
关键词
Aging; arrhythmias; cognitive dysfunction; diabetes; excitation-contraction coupling; heart failure; IP3 receptors metabolism; mitochondria; neurodegenerative disorders; RyR; skeletal muscle
资金
- American Heart Association (AHA) [13POST16810041, 15SDG25300007]
- NIH [R01-HL102040, R01-HL061503, R01AR060037]
- Leducq Foundation
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL061503, R01HL102040] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR060037] Funding Source: NIH RePORTER
Calcium (Ca2+) release from intracellular stores controls numerous cellular processes, including cardiac and skeletal muscle contraction, synaptic transmission and metabolism. The ryanodine receptors (RyRs: RyR1, RyR2, RyR3) and inositol 1,4,5-trisphosphate receptors (IP3Rs: IP3R1, IP3R2, IP3R3) are the major Ca2+ release channels (CRCs) on the endo/sarcoplasmic reticulum (ER/SR). RyRs and IP3Rs comprise macromolecular signaling complexes that include modulatory proteins which regulate channel activity in response to extracellular signals resulting in intracellular Ca2+ release. Here we focus on the roles of CRCs in heart, skeletal muscle, brain, metabolism, and aging.
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