Regioselective Hydrodehalogenation of Aromatic α- and β-Halo carbonyl Compounds by CuI in Isopropanol

An operationally efficient and regioselective hydrodehalogenation methodology of aromatic alpha- and beta-halo carbonyl compounds has been developed using CuI in isopropanol at 90 degrees C under basic condition. The catalytic system effectively dehalogenates chloride, bromide, and iodide groups and afforded high yield (up to 97 %) as carbonyl compounds. The methodology is environmentally friendly and demonstrates excellent tolerance to a broad range of electronically rich and poor substituents.