期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2019, 期 6, 页码 1350-1354出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201801689
关键词
Continuous flow; Microreactors; Synthetic methods; Phenothiazine; Heterocycles
资金
- Agency for Innovation by Science and Technology in Flanders (IWT)
- 3M
- Fund for Scientific Research-Flandres (FWO)
The continuous flow synthesis of a model phenothiazine antipsychotic is presented herein, using 3-chloropropionyl chloride as a central building block. The basic phenothiazine-derived scaffold is (atom)-efficiently and mildly synthesized with the aim to present continuous flow technology as a contributor to fast and efficient syntheses of challenging APIs, that are nowadays experiencing supply disruptions and global shortages.
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