期刊
EUROPEAN JOURNAL OF NUTRITION
卷 59, 期 1, 页码 195-204出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00394-019-01899-5
关键词
Vitamin D; Adipokines; Obesity; Randomized controlled trial
资金
- Monash University
- National Health and Medical Research Council (NHMRC) of Australia [APP490977]
- National Heart Foundation [100864]
- NHMRC [APP1047897]
Purpose Vitamin D regulates adipokine production in vitro; however, clinical trials have been inconclusive. We conducted secondary analyses of a randomized controlled trial to examine whether vitamin D supplementation improves adipokine concentrations in overweight/obese and vitamin D-deficient adults. Methods Sixty-five individuals with a BMI >= 25 kg/m(2) and 25-hydroxyvitamin D (25(OH)D) <= 50 nmol/L were randomized to oral cholecalciferol (100,000 IU single bolus followed by 4,000 IU daily) or matching placebo for 16 weeks. We measured BMI, waist-to-hip ratio, % body fat (dual X-ray absorptiometry), serum 25(OH)D (chemiluminescent immunoassay) and total adiponectin, leptin, resistin, and adipsin concentrations (multiplex assay; flow cytometry). Sun exposure, physical activity, and diet were assessed using questionnaires. Results Fifty-four participants completed the study (35M/19F; mean age = 31.9 +/- 8.5 years; BMI = 30.9 +/- 4.4 kg/m(2)). After 16 weeks, vitamin D supplementation increased 25(OH)D concentrations compared with placebo (57.0 +/- 21.3 versus 1.9 +/- 15.1 nmol/L, p < 0.001). There were no differences between groups for changes in adiponectin, leptin, resistin, or adipsin in unadjusted analyses (all p > 0.05). After adjustment for baseline values, season, sun exposure, and dietary vitamin D intake, there was a greater increase in adiponectin (beta[95%CI] = 13.7[2.0, 25.5], p = 0.02) and leptin (beta[95%CI] = 22.3[3.8, 40.9], p = 0.02) in the vitamin D group compared with placebo. Results remained significant after additional adjustment for age, sex, and % body fat (p < 0.02). Conclusions Vitamin D may increase adiponectin and leptin concentrations in overweight/obese and vitamin D-deficient adults. Further studies are needed to clarify the molecular interactions between vitamin D and adipokines and the clinical implications of these interactions in the context of obesity.
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