期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 162, 期 -, 页码 435-447出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2018.11.027
关键词
Heterocycle; Triazine; Anti-Inflammatory activity; Systematic review; Inflammatory mediator
资金
- Universidad Tecnologica de Pereira [9-16-3]
- Universidad del Valle
- Programa Jovenes Investigadores e Innovadores 2016 (COL-CIENCIAS, Convocatoria 761) [5508/2017]
Triazines are heterocyclic compounds with a variety of biological activities that have been increasingly studied in recent years due to their versatile structure (three isoforms) and the different derivatives that can be synthesized from them to ensure functional motifs. This systematic review provides the evidence in the literature of the in vitro and in vivo anti-inflammatory activity of triazine derivatives from 2008 to June 2018. Four bibliographical databases were consulted (PubMed, Web of Science, EMBASE and Scopus), and a total of 48 studies were included in this paper based on our eligibility criteria. Although 35.17% of evaluated triazines were demonstrated to be promising anti-inflammatory agents, further studies need to be conducted to explore their pharmacological profiles in the medical research of drug discovery to control the risk factors and pathophysiology of several chronic inflammation-based diseases. (C) 2018 Elsevier Masson SAS. All rights reserved.
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