期刊
IMMUNE NETWORK
卷 15, 期 1, 页码 1-8出版社
KOREA ASSOC IMMUNOLOGISTS
DOI: 10.4110/in.2015.15.1.1
关键词
Dendritic cells; Gut; Regulatory T cells; Th17; Secretory IgA
类别
资金
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT and future Planning [NRF-2014R1A1A1002129, NRF-2014R1A2A2A 01002576]
Innate immune cells survey antigenic materials beneath our body surfaces and provide a front-line response to internal and external danger signals. Dendritic cells (DCs), a subset of innate immune cells, are critical sentinels that perform multiple roles in immune responses, from acting as principal modulators to priming an adaptive immune response through antigen-specific signaling. In the gut, DCs meet exogenous, non-harmful food antigens as well as vast commensal microbes under steady-state conditions. In other instances, they must combat pathogenic microbes to prevent infections. In this review, we focus on the function of intestinal DCs in maintaining intestinal immune homeostasis. Specifically, we describe how intestinal DCs affect IgA production from B cells and influence the generation of unique subsets of T cell.
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