期刊
EUROPEAN JOURNAL OF EPIDEMIOLOGY
卷 34, 期 5, 页码 439-445出版社
SPRINGER
DOI: 10.1007/s10654-018-0477-6
关键词
Environment; Epidemiology; Cancer; Somatic mutations; Risk factors
资金
- French Ligue contre le Cancer (Appel a projets 2016 Recherche en Epidemiologie)
- French Institut National du Cancer [11330]
- NATIONAL CANCER INSTITUTE [ZIACP010131] Funding Source: NIH RePORTER
- MRC [MR/L01341X/1] Funding Source: UKRI
An intense scientific debate has recently taken place relating to the bad luck hypothesis in cancer development, namely that intrinsic random, and therefore unavoidable, mutagenic events would have a predominant role in tumorigenesis. In this article we review the main contributions to this debate and explain the reasons why the claim that cancer is mostly explained by intrinsic random factors is unsupported by data and theoretical models. In support of this, we present an analysis showing that smoking-induced mutations are more predictive of cancer risk than the lifetime number of stem cell cellular divisions.
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