期刊
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
卷 75, 期 3, 页码 303-311出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00228-018-2601-7
关键词
Upper respiratory tract infection; Vitamin C; Infants; Adolescents; Systematic review
PurposeUpper respiratory tract infection (URTI) is a common infection in children, generally caused by viral respiratory infection. Vitamin C is currently proposed as prophylaxis for URTI. The purpose of this study was to assess the effectiveness of vitamin C administration in children for the prevention and reduced duration of URTI through a systematic literature review.MethodsReview of the literature conducted between October 2017 and January 2018 in the main medical databases (CENTRAL, Medline and Embase) and by a gray literature approach. The selection criteria were: double-blind randomized controlled trials (RCTs) comparing vitamin C use to placebo in children aged 3months to 18years without chronic infection. Efficacy was assessed in terms of incidence, duration and severity of symptoms of URTI. A meta-analysis was conducted where possible.ResultsEight RCTs, including 3135 children aged 3months to 18years, were selected. Quantitative analysis showed no difference between vitamin C administration and placebo (odds ratio=0.75, 95% CI [0.54-1.03], p=0.07, I-2=74%). Vitamin C administration was found to decrease the duration of URTI by 1.6days (standardized mean differences=-0.30 [-0.53; -0.08], p=0.009, I-2=70%). Children under 6years of age benefit from more effective vitamin C supplementation associated with echinacea. No serious adverse events were reported.ConclusionsAlthough no preventive effects were found, vitamin C intake reduced the duration of URTI. Considering the frequency of URTI, the inappropriate prescription of antibiotics, and the safe nature of vitamin C, its supplementation is justified, especially in children under 6years of age and those who present a high frequency of URTI. There is a sound rationale for further trials with greater statistical power among children of this age.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据