期刊
EUROPEAN JOURNAL OF CELL BIOLOGY
卷 98, 期 2-4, 页码 74-80出版社
ELSEVIER GMBH
DOI: 10.1016/j.ejcb.2018.12.002
关键词
Kinesin-6; KIF20A; Microtubule; Anaphase; Spindle assembly; Mitosis
类别
资金
- Health and Family Planning Commission of Fujian Province [2018-1-69]
- Fujian Medical University [2017XQ1001]
- Fujian Medical University high level talents scientific research start-up funding project [XRCZX2017025]
- College Students' innovation and entrepreneurship training program [201810392035]
Mitotic kinesin is crucial for spindle assembly and chromosome segregation in cell division. KIF20A/MKlp2, a member of kinesin-6 subfamily, plays important roles in the central spindle organization at anaphase and cytokinesis. In this review, we briefly introduce the discovery and classification of kinesin-6 motors in model organisms, and summarize the biochemical features and mechanics of KIF20A proteins. We emphasize the complicated interactions of KIF20A with partner proteins, including MKlp1, Plk1 and Rab6. Particularly, we highlight the regulation of Cdk1 and chromosomal passenger complex on kinesin-6 KIF20A at late stage of mitosis. We summarized the multiple functions of KIF20A in central spindle assembly and the formation of cleavage furrow in both mitosis and meiosis. In addition, we conclude the expression patterns of KIF20A in tumorigenesis and its applications in tumor therapy.
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