期刊
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
卷 26, 期 4, 页码 3659-3665出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s11356-018-3907-9
关键词
Diazinon; Oxidative stress; Curcumin; Quercetin; Antioxidant; Anti-inflammatory; Acetylcholinesterase
资金
- Deanship of Scientific Research at King Saud University [RGP-018]
The ubiquitous use of diazinon (DZN, an organophosphorus insecticide) has increased the probability of occupational, public, and the ecosystem exposure; these exposures are linked to negative health outcomes. The flavonoids curcumin (CUR) and quercetin (QUE) exert significant anti-inflammatory and antioxidant activities against toxicants, including insecticides. However, it is unclear whether their combination enhances these activities. Therefore, 40 albino rat were divided randomly into the CTR, DZN, CUR+DZN, QUE+DZN, and CUR+QUE+DZN groups, which are treated daily via gavage for 28days. DZN induced neurohepatic inflammation and oxidative damage, which was confirmed by significant (P<0.05) induction of aspartate and alanine aminotransferases, alkaline phosphatase, lactate dehydrogenase, -glutamyl transferase, and tumor necrosis factor- and inhibition of acetylcholinesterase activity. Furthermore, the liver and brain of DZN-exposed rats exhibited a notable elevation in MDA level paralleled with reduction in antioxidant molecules, i.e., glutathione, superoxide dismutase, glutathione peroxidase, and catalase. The pretreatment of DZN-intoxicated rats with CUR or QUE substantially mitigated neurohepatic dysfunction and inflammation and improved liver and brain antioxidant status with reducing oxidative stress levels. Furthermore, pretreatment with CUR+QUE synergistically restored the neurohepatic dysfunction and oxidative levels to approximately normal levels. The overall results suggested that CUR or QUE inhibits DZN-mediated neurohepatic toxicity via their favorable anti-inflammatory, antioxidant, and free radical-scavenging activities. Moreover, both QUE and CUR may be mutual adjuvant agents against oxidative stress neurohepatic damages.
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