期刊
ENVIRONMENTAL MICROBIOLOGY
卷 21, 期 3, 页码 1099-1112出版社
WILEY
DOI: 10.1111/1462-2920.14529
关键词
-
类别
资金
- Applied Molecular Biosciences Unit-UCIBIO - FCT/MCTES [UID/Multi/04378/2019]
- FCT/MCTES [RECI/BBB-BQB/0230/2012, PTDC/QUIQUI/119116/2010, PTDC/FIS-NAN/0117/2014, IF/00700/2014]
- Associate Laboratory for Green Chemistry- LAQV - FCT/MCTES [UID/QUI/50006/2019]
- 7th Framework Programme (FP7/2007-2013) [PCOFUND-GA-2009-246542, DFRH/WIIA/102/2011, SFRH/BI/52130/2013]
The search for new and effective strategies to reduce bacterial biofilm formation is of utmost importance as bacterial resistance to antibiotics continues to emerge. The use of anti-biofilm agents that can disrupt recalcitrant bacterial communities can be an advantageous alternative to antimicrobials, as their use does not lead to the development of resistance mechanisms. Six MAR4 Streptomyces strains isolated from the Madeira Archipelago, at the unexplored Macaronesia Atlantic ecoregion, were used to study the chemical diversity of produced hybrid isoprenoids. These marine actinomycetes were investigated by analysing their crude extracts using LC-MS/MS and their metabolomic profiles were compared using multivariate statistical analysis (principal component analysis), showing a separation trend closely related to their phylogeny. Molecular networking unveiled the presence of a class of metabolites not previously described from MAR4 strains and new chemical derivatives belonging to the napyradiomycin and marinone classes. Furthermore, these MAR4 strains produce metabolites that inhibit biofilm formation of Staphylococcus aureus and Marinobacter hydrocarbonoclasticus. The anti-biofilm activity of napyradiomycin SF2415B3 (1) against S. aureus was confirmed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据