期刊
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
卷 60, 期 4, 页码 368-384出版社
WILEY
DOI: 10.1002/em.22267
关键词
SOS response; mutator effect; TLS; RecA; LexA regulon; Escherichia coli
资金
- International Ph.D. Projects Program of the Foundation for Polish Science Studies of Nucleic Acids and Proteins - from Basic to Applied Research [MPD/2009-3/2]
- European Union Regional Development Fund
- National Science Center, Poland [2015/18/M/NZ3/00402]
- Foundation for Polish Science [TEAM/2011-8/1]
- European Union - Regional Development Fund New players involved in the maintenance of genomic stability
Genomes of all living organisms are constantly threatened by endogenous and exogenous agents that challenge the chemical integrity of DNA. Most bacteria have evolved a coordinated response to DNA damage. In Escherichia coli, this inducible system is termed the SOS response. The SOS global regulatory network consists of multiple factors promoting the integrity of DNA as well as error-prone factors allowing for survival and continuous replication upon extensive DNA damage at the cost of elevated mutagenesis. Due to its mutagenic potential, the SOS response is subject to elaborate regulatory control involving not only transcriptional derepression, but also post-translational activation, and inhibition. This review summarizes current knowledge about the molecular mechanism of the SOS response induction and progression and its consequences for genome stability. Environ. Mol. Mutagen. 60:368-384, 2019. (c) 2018 The Authors. Environmental and Molecular Mutagenesis published by Wiley Periodicals, Inc. on behalf of Environmental Mutagen Society.
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