期刊
ADIPOCYTE
卷 4, 期 2, 页码 123-128出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/21623945.2014.981438
关键词
browning; beige cells; HFD; insulin resistance; M2 ATM; macrophages; preadipocyte differentiation; RIP140; obesity
资金
- NIH [DK54733, DK60521, DK54733-11S, 3 R01 DK60521-12S1]
- Dean's Commitment and the Distinguished McKnight Professorship of University of Minnesota
We recently exploited a transgenic approach to coerce macrophage anti-inflammatory M2 polarization in vivo by lowering Receptor Interacting Protein 140 (RIP140) level in macrophages (m phi RIP140KD), which induced browning of white adipose tissue (WAT). In vitro, conditioned medium from cultured adipose tissue macrophages (ATMs) of m phi RIP140KD mice could trigger preadipocytes' differentiation into beige cells. Here we describe a cell therapy for treating high fat diet (HFD)-induced insulin resistance (IR). Injecting M2 ATMs retrieved from the WAT of m phi RIP140KD mice into HFD-fed obese adult wild-type mice effectively triggers their WAT browning, reduces their pro-inflammatory responses, and improves their insulin sensitivity. These data provide a proof-of-concept that delivering engineered anti-inflammatory macrophages can trigger white fat browning, stimulate whole-body thermogenesis, and reduce obesity-associated IR.
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