期刊
EMBO REPORTS
卷 20, 期 2, 页码 -出版社
WILEY
DOI: 10.15252/embr.201846612
关键词
differentiation; epidermis; LINC00941; long non-coding RNA; SPRR5
资金
- Deutsche Forschungsgemeinschaft [SFB 960, KR 3468/2-1]
- Beiersdorf AG
Several long non-coding RNAs (lncRNAs) act as regulators of cellular homeostasis; however, few of these molecules were functionally characterized in a mature human tissue environment. Here, we report that the lncRNA LINC00941 is a crucial regulator of human epidermal homeostasis. LINC00941 is enriched in progenitor keratinocytes and acts as a repressor of keratinocyte differentiation. Furthermore, LINC00941 represses SPRR5, a previously uncharacterized molecule, which functions as an essential positive regulator of keratinocyte differentiation. Interestingly, 54.8% of genes repressed in SPRR5-deficient epidermal tissue are induced in LINC00941-depleted organotypic epidermis, suggesting a common mode of action for both molecules.
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