期刊
ELECTROANALYSIS
卷 31, 期 2, 页码 390-397出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.201800525
关键词
Graphene; dopamine; serotonin; chemometrics; voltammetry
资金
- Spanish Ministry of Economy and Innovation, MINECO (Madrid) [CTQ2016-80170-P]
- AGAUR, Generalitat de Catalunya
- European Social Fund, European Union
- program ICREA Academia
This work explores an electrode modified with electrochemically reduced graphene oxide (ERGO) for the voltammetric resolution of mixtures of neurotransmitters and its most common interferents. This enhanced sensitivity device coupled with advanced chemometric tools, such as artificial neural networks (ANNs), is able to resolve and quantify complex mixtures with overlapped signals. In this case, it has been applied to dopamine (DA), serotonin (5-hydroxytryptamine, 5-HT) and its main physiologic interferents, ascorbic acid (AA) and uric acid (UA), which play a relevant role in human body. The results obtained for individual analysis make evident a higher sensitivity of the developed sensor than the unmodified electrode. Furthermore, it has been attained an ANN response model with good correlation ability allowing the separation and quantification of each compound with comparison slope of predicted vs. expected concentrations with correlation better than 0.974. In short, the developed ERGO-modified sensor not only improved the signal but it also permitted resolving and quantifying each compound in complex mixtures when the proper chemometric treatment was used.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据