期刊
DRUG DEVELOPMENT RESEARCH
卷 80, 期 1, 页码 138-146出版社
WILEY
DOI: 10.1002/ddr.21477
关键词
aminonaphthoquinones; antibacterial activity; anticancer activity; antifungal activity; minimum inhibitory concentration
资金
- National Research Foundation [105993]
In this study, we report on the inhibitory activity of synthesized aminonaphthoquinones against two bacterial and one fungal species to determine their antimicrobial properties. A minimum inhibitory concentration (MIC) of 7.8 mu g/mL was obtained against the fungus, Candida albicans, which was better than that of Amphotericin B (MIC = 31.25 mu g/mL). Escherichia coli (Gram -), was inhibited at a MIC of 23.4 mu g/mL and Staphylococcus aureus (Gram +) at a MIC of 31.3 mu g/mL. The aminonaphthoquinones were also screened against HCT116 colon, PC3 prostate and HepG2 liver cancer cell lines to evaluate their cytostatic effects. They had potent activity (GI(50) = 5.87-9.90 mu M) which was about three-6-fold better than that of parthenolide (GI(50) = 25.97 mu M) against the prostate cancer cell line. These compounds were generally more selective for cancer cells than for normal human lung fetal fibroblasts (WI-38).
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