期刊
DISEASE MODELS & MECHANISMS
卷 11, 期 10, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dmm.036236
关键词
Metastasis; Inflammation; Immunotherapy; (Pre-)metastatic niche
资金
- KWF Kankerbestrijding [KWF10083, KWF10623]
- European Research Council [InflaMet 615300]
- Oncode Institute
- Beug Foundation for Metastasis Research
- Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung [P2FRP3 171794]
- EMBO
- Swiss National Science Foundation (SNF) [P2FRP3_171794] Funding Source: Swiss National Science Foundation (SNF)
Metastatic disease is the leading cause of death in cancer patients. Metastasis formation involves a cascade of events for which the underlying mechanisms are still poorly understood. During the metastatic cascade, cancer cells tightly interact with the immune system and they influence each other, both in the tumor microenvironment and systemically. The crosstalk between cancer and immune cells adds another layer of complexity to our understanding of metastasis formation, but at the same time new therapeutic opportunities for cancer patients. The intensifying development of immunotherapeutic strategies calls for a better understanding of immune regulation of metastasis in order to maximize the therapeutic benefit for patients with metastatic disease. In this Review and accompanying poster, we describe the main mechanisms of immune regulation of metastasis that have been reported to date, and present promising immunotherapeutic options that are currently available, or may become so in the near future, to tackle metastasis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据