期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 43, 期 -, 页码 1234-1240出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20150164
关键词
eukaryotic initiation factor 2B (eIF2B); integrated stress response; integrated stress response inhibitor (ISRIB); protein synthesis; vanishing white matter
资金
- UK Biotechnology & Biological Sciences Research Council [BB/J007706/1]
- Biotechnology and Biological Sciences Research Council [BB/J007706/1, BB/G008396/1] Funding Source: researchfish
- BBSRC [BB/G008396/1, BB/J007706/1] Funding Source: UKRI
The eukaryotic translation initiation factor (eIF) eIF2B is a key regulator of mRNA translation, being the guanine nt exchange factor (GEF) responsible for the recycling of the heterotrimeric G-protein, eIF2, which is required to allow translation initiation to occur. Unusually for a GEF, eIF2B is a multi-subunit protein, comprising five different subunits termed alpha through epsilon in order of increasing size. eIF2B is subject to tight regulation in the cell and may also serve additional functions. Here we review recent insights into the subunit organization of the mammalian eIF2B complex, gained both from structural studies of the complex and from studies of mutations of eIF2B that result in the neurological disorder leukoencephalopathy with vanishing white matter (VWM). We will also discuss recent data from yeast demonstrating a novel function of the eIF2B complex key for translational regulation.
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