期刊
DEVELOPMENTAL CELL
卷 48, 期 1, 页码 76-+出版社
CELL PRESS
DOI: 10.1016/j.devcel.2018.11.029
关键词
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资金
- Drosophila Genetics Resource Center (NIH grant) [2P40OD010949]
- CNRS, INSERM
- European Research Council [268813]
- ARC [PGA120150202355]
- Labex Signalife program [ANR-11-LABX-0028-01]
- French government
- Fondation pour la Recherche Medicale [FDT20170437244]
Developing organisms use fine-tuning mechanisms to adjust body growth to ever-changing nutritional conditions. In Drosophila, the secretory activity of insulin-producing cells (IPCs) is central to couple systemic growth with amino acids availability. Here, we identify a subpopulation of inhibitory neurons contacting the IPCs (IPC-connecting neurons or ICNs) that play a key role in this coupling. We show that ICNs respond to growth-blocking peptides (GBPs),a family of fat-body-derived signals produced upon availability of dietary amino acids. We demonstrate that GBPs are atypical ligands for the fly EGF receptor (EGFR). Upon activation of EGFR by adipose GBPs, ICN-mediated inhibition of IPC function is relieved, allowing insulin secretion. Our study reveals an unexpected role for EGF-like metabolic hormones and EGFR signaling as critical modulators of neural activity, coupling insulin secretion to the nutritional status.
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