期刊
DEVELOPMENT
卷 145, 期 20, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.164384
关键词
GATA factors; Gene redundancy; Genetics; Lineage specification; Mouse development; Transcription; Human diseases
资金
- Canadian Institutes of Health Research [MOP-130431]
- Fonds de la Recherche du Quebec-Sante
- KRESCENT fellowship from the Kidney Foundation of Canada
The GATA family of transcription factors is of crucial importance during embryonic development, playing complex and widespread roles in cell fate decisions and tissue morphogenesis. GATA proteins are essential for the development of tissues derived from all three germ layers, including the skin, brain, gonads, liver, hematopoietic, cardiovascular and urogenital systems. The crucial activity of GATA factors is underscored by the fact that inactivating mutations in most GATA members lead to embryonic lethality in mouse models and are often associated with developmental diseases in humans. In this Primer, we discuss the unique and redundant functions of GATA proteins in tissue morphogenesis, with an emphasis on their regulation of lineage specification and early organogenesis.
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