期刊
CURRENT MEDICINAL CHEMISTRY
卷 25, 期 40, 页码 5588-5596出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867324666170801095850
关键词
Sarcopenia; aging; mitochondria; mitophagy; phytochemical; nicotinamide adenine dinucleotide
资金
- Intramural Research Program of the National Institute on Aging
Sarcopenia, or age-related muscle decline, occurs in most organisms and burdens both human health and the healthcare system. As our population ages, additional options for treating sarcopenia are needed. Mitochondrial dysfunction is implicated in the onset of sarcopenia, so therapies directed at improving mitochondrial function in muscle should be considered. Many naturally-occurring compounds, derived from commonly consumed foods, possess anti-sarcopenic effects, such asnicotinamide riboside, tomatidine, and Urolithin A. These naturally-occurring compounds can improve mitochondrial health and efficiency by modulating mitochondrial biogenesis, cellular stress resistance, or mitophagy. Further research should assess whether compounds that improve mitochondrial health can attenuate sarcopenia in humans.
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