期刊
CURRENT BIOLOGY
卷 28, 期 24, 页码 3948-+出版社
CELL PRESS
DOI: 10.1016/j.cub.2018.11.020
关键词
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资金
- National Key Research and Development Program of China Stem Cell and Translational Research [2016YFA0102500]
- National Natural Science Foundation of China [31671105, 31471083, 81671374]
- Science Fund for Creative Research Group of China [61721092]
- Wuhan National Laboratory for Optoelectronics
Orchestration of sleep and feeding behavior is essential for organismal health and survival. Although sleep deprivation promotes feeding and starvation suppresses sleep, the underlying neural mechanisms remain largely unknown. Here, we showed that starvation in mice potently promoted arousal and activated calretinin neurons (CR+) in the paraventricular thalamus (PVT). Direct activation of PVTCR+ neurons promoted arousal, and their activity was necessary for starvation-induced sleep suppression. Specifically, the PVTCR+-bed nucleus of the stria terminalis (BNST) circuit rapidly initiated arousal. Selective inhibition of BNST-projecting PVT neurons opposed arousal during starvation. Taken together, our results define a cell-type-specific neural circuitry modulating starvation-induced arousal and coordinating the conflict between sleeping and feeding.
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