期刊
CURRENT ALZHEIMER RESEARCH
卷 16, 期 2, 页码 109-115出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1567205016666181212162424
关键词
Pain intensity; pain interference; dementia; Alzheimer's disease; remediable risk factor
资金
- National Institutes of Health [NIA 2 P01 AG03949, NIA 1R01AG039409-01, NIA R03 AG045474, NIH K01AG054700]
- Leonard and Sylvia Marx Foundation
- Czap Foundation
- NATIONAL INSTITUTE ON AGING [K23AG049466, K01AG054700] Funding Source: NIH RePORTER
Background: Chronic pain is common among older adults and is associated with cognitive dysfunction based on cross-sectional studies. However, the longitudinal association between chronic pain and incident dementia in community-based samples is unknown. Objective: We aimed to evaluate the association of pain intensity and pain interference with incident dementia in a community-based sample of older adults. Methods: Participants were 1,114 individuals 70 years of age or older from Einstein Aging Study (EAS), a longitudinal cohort study of community-dwelling older adults in the Bronx County, NY. The primary outcome measure was incident dementia, diagnosed using DSM-IV criteria. Pain intensity and Interference in the month prior to first annual visit were measured using items from the SF-36 questionnaire. Pain intensity and pain interference were assessed as predictors of time to incident dementia using Cox proportionate hazards models while controlling for potential confounders. Results: Among participants, 114 individuals developed dementia over an average 4.4 years (SD=3.1) of follow-up. Models showed that pain intensity had no significant effect on time to developing dementia, whereas higher levels of pain interference were associated with a higher risk of dementia. In the model that included both pain intensity and interference as predictors of incident dementia, pain interference had a significant effect on incident dementia, and pain intensity remained non-significant. Conclusion: As a potential remediable risk factor, the mechanisms linking pain interference to cognitive decline merit further exploration.
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