期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 43, 期 -, 页码 104-107出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20140286
关键词
collagen; COPII; secretion; SNARE; TANGO
资金
- Deutsche Forschungsgemeinschaft (DFG)
- German Research Foundation fellowship [ER 681/1-1]
- Plan Nacional [BFU2008-00414]
- Consolider [CSD2009-00016]
- Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR)-Catalan Government [SGR2009-1488]
- European Research Council [268692]
- ICREA Funding Source: Custom
Collagens are secreted into the extracellular space where they assemble into a large complex protein network to form basement membrane and extracellular matrix. Collagens are therefore essential for cell attachment, tissue organization and the overall survival of all multicellular organisms. Collagens are synthesized in the endoplasmic reticulum (ER) but they are too big to fit into a conventional coat protein complex II (COPII) transport carrier of 60-90 nm average diameter. How are these molecules exported from the ER and then transported along the secretory pathway? We describe here the involvement of special packing machinery composed of hetero oligomers of transport and Golgi organization 1 (TANGO1) and cutaneous T-cell lymphoma-associated antigen 5 (cTAGE5) in the export of procollagen VII from the ER.
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