期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 173, 期 -, 页码 698-708出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2018.10.045
关键词
PAMAM dendrimers; Photothermal therapy; Polydopamine; Doxorubicin; Nanomedicine; Drug delivery
资金
- National Center for Research and Development [LIDER/11/0055/L-7/15/NCBiR/2016]
- National Science Centre Poland [UMO-2014/13/D/ST5/02793]
- Poznan University of Technology [03/32/DSPB/0806]
- Foundation for Polish Science (FNP) through a START scholarship
Here we report the synthesis of multifunctional nanocarriers based on PAMAM dendrimers generation (G) 4.0, 5.0 and 6.0 fixed to polydopamine (PDA) coated magnetite nanoparticles (Fe3O4). Synthesized nanoplatforms were characterized by transmission electron microscopy (TEM), the electrokinetic (zeta) potential, Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS) and magnetic resonance imaging (MRI). Further, we show as a proof of concept that nanocarriers functionalized with G 5.0 could be successfully applied in combined chemo- and photothermal therapy (CT-PTT) of the liver cancer cells. The cooperative effect of the modalities mentioned above led to higher mortality of cancer cells when compared to their individual performance. Moreover, the performed in vitro studies revealed that the application of dual therapy triggered the desired cell death mechanism-apoptosis. Furthermore, performed tests using Magnetic Resonance Imaging (MRI) showed that our materials have competitive contrast properties. Overall, the functionality of dendrimers has been extended by merging them with magnetic nanoparticles resulting in multifunctional hybrid nanostructures that are promising smart drug delivery system for cancer therapy.
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