期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 173, 期 -, 页码 258-265出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2018.09.081
关键词
NIR light-triggered drug release; Anticancer; PLGA fibers; Electrospinning; Photothermal therapy
资金
- Basic Science Research Programs through the National Research Foundation of Korea (NRF) - Ministry of Education (MOE) [NRF-2015R1D1A1A01059812, 2018R1D1A1B07043878]
- National Research Foundation of Korea [2018R1D1A1B07043878] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This work introduces a new fibrous system for synergistic cancer therapy. The system consists of poly(D,L-lactic-co-glycolic acid) (PLGA) fibers with a core encapsulating an anticancer drug and a shell entrapping gold na-norods (AuNRs) as a photothermal agent. On exposure to NIR light, the photothermal agent generates heat to raise the local temperature of the fibers. If the temperature is above a glass transition (T-g) of the polymer, the polymer chains will be mobile, increasing free volume in size within the shell. As a result, a rapid release of the drug can be achieved. When NIR light is turned off, the release will stop with inactivity of the photothermal agent, followed by freezing the segmental motion of the polymer chains. The on-off switching of NIR light in a time-controllable manner allows a repeated and accurate release of the drug, leading to the significant enhancement of anticancer activity in combination with the hyperthermia effect arising from the photothermal agent.
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