4.7 Article

Based on reduced graphene oxide-copper sulfide-carbon nitride nanosheets composite electrochemiluminescence sensor for determination of gatifloxacin in mouse plasma

期刊

COLLOIDS AND SURFACES B-BIOINTERFACES
卷 173, 期 -, 页码 378-385

出版社

ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2018.10.003

关键词

Electrochemiluminescence sensor; Carbon nitride; Reduced graphene oxide; Copper sulfide; Gatifloxacin hydrochloride

资金

  1. National Natural Science Foundation of China [21765004, 21365006]
  2. Guangxi Science Foundation of China [2014GXNSFDA118004, 1598025-4]
  3. Youth Visiting Project for Young Key Teachers in Institutions of Higher Learning
  4. State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University) [CMEMR2017-A5]

向作者/读者索取更多资源

A new method for determination of gatifloxacin hydrochloride (GAT) by reduced graphene oxide-copper sulfide (rGO-CuS) composite coupled with graphite-like carbon nitride nanosheets (g-C3N4 NSs) modified glassy carbon electrode was developed. In this work, rGO-CuS composite was synthesized by one-pot hydrothermal method and used for enhancing sensitivity of GAT. g-C3N4 NSs were synthesized as radiant agent. The sensor characteristics of electrochemistry and electrochemiluminescence (ECL) were investigated. The ECL intensity has enhanced four-fold after modifying with rGO-CuS composite. The results can be ascribed to the presence of rGO-CuS composite on the electrode surface that facilitates the electron transfer rate between the electroactive center of g-C3N4 NSs and the electrode. Under the optimum experimental conditions (photomultiplier tuber for 800 V, scan rate for 0.1 V/s, 0.1 mol/L PBS (pH 7.5) and 1.0 x 10(-2) mol/L K2S2O8), the linear range for GAT was from 1.0 x 10(-4) to 1.0 x 10(-8) mol/L (R-2 = 0.9991) with detection limit of 3.5 x 10(-9) mol/L (S/N = 3). RSD for ECL intensity was 4.8% (n = 10). The recoveries of GAT in mouse plasma samples were from 98.36 to 104.7%. The sensor showed the advantages of low cost, high sensitivity and wide application in drug analysis.

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