期刊
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
卷 561, 期 -, 页码 332-340出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfa.2018.10.072
关键词
Polydopamine; Layer-by-layer assembly; Chemotherapy; Photothermal; Therapy
资金
- National Natural Science Foundation of China [21503277]
- Shandong Provincial Natural Science Foundation, China [ZR2017LB028]
- Key R&D Program of Shandong Province [2018GSF118032]
The combined therapeutic strategy have aroused significant interest in cancer therapy due to its enhanced treatment efficacy and reduced side effects. This paper describes the combined chemo- and photothermal therapy of cancer based on PDA@(PDDA-ADA) 3-Dox nanocomposites. Polydopamine (PDA) serves not only as photothermal agent with strong near infrared absorbance and high energy conversion efficiency, but also as a core material to carry multilayer films formed by alternatively deposition of positively charged poly(diallyldimethylammonium chloride) (PDDA) and negatively charged alginate dialdehyde (ADA) through layer-by-layer (LBL) method. Doxorubicin hydrochloride (Dox) was loaded to the PDA@(PDDA-ADA) 3 nanoplatform via Schiff base bond and electrostatic interaction. The fabricated PDA@(PDDA-ADA)(3)-Dox nanocomposites exhibit outstanding pH-sensitive drug release, good biocompatibility and high photothermal conversion efficiency. These features make them achieve excellent anticancer therapeutic efficacy by combined chemo- and photothermal therapy. This work points that the PDA-based nanoplatform can be a universal scaffold for cancer treatment.
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