期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 43, 期 -, 页码 73-78出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20140246
关键词
Arabidopsis; cell plate; cytokinesis; membrane fusion; membrane traffic; soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)
资金
- Deutsche Forschungsgemeinschaft (DFG)
Cytokinesis separates the forming daughter cells. Higher plants have lost the ability to constrict the plasma membrane (PM) in the division plane. Instead, trans-Golgi network (TGN)-derived membrane vesicles are targeted to the centre of the division plane and generate, by homotypic fusion, the partitioning membrane named cell plate (CP). The CP expands in a centrifugal fashion until its margin fuses with the PM at the cortical division site. Mutant screens in Arabidopsis have identified a cytokinesis-specific syntaxin named KNOLLE and an interacting Sec1/Munc18 (SM) protein named KEULE both of which are required for vesicle fusion during cytokinesis. KNOLLE is only made during M-phase, targeted to the division plane and degraded in the vacuole at the end of cytokinesis. Here we address mechanisms of KNOLLE trafficking and interaction of KNOLLE with different soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptor (SNARE) partners and with SM-protein KEULE, ensuring membrane fusion in cytokinesis.
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