期刊
EXPERIMENTAL NEUROBIOLOGY
卷 24, 期 4, 页码 285-300出版社
KOREAN SOC BRAIN & NEURAL SCIENCE, KOREAN SOC NEURODEGENERATIVE DISEASE
DOI: 10.5607/en.2015.24.4.285
关键词
autism spectrum disorder; construct validity; face validity; predictive validity; animal model; social communication deficit
资金
- Ministry of Health and Welfare, Republic of Korea [A120029]
- National Research Foundation of Korea [2014R1A2A2A01003079]
- National Research Foundation of Korea [2014R1A2A2A01003079] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The valproic acid (VPA) animal model of autism spectrum disorder (ASD) is one of the most widely used animal model in the field. Like any other disease models, it can't model the totality of the features seen in autism. Then, is it valid to model autism? This model demonstrates many of the structural and behavioral features that can be observed in individuals with autism. These similarities enable the model to define relevant pathways of developmental dysregulation resulting from environmental manipulation. The uncovering of these complex pathways resulted to the growing pool of potential therapeutic candidates addressing the core symptoms of ASD. Here, we summarize the validity points of VPA that may or may not qualify it as a valid animal model of ASD.
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