期刊
CLINICS IN PERINATOLOGY
卷 46, 期 1, 页码 145-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.clp.2018.09.007
关键词
Necrotizing enterocolitis; TLR4; Inflammation; Epithelial cells
资金
- National Institutes of Health [K08DK101608, R03DK111473]
- March of Dimes Foundation [5-FY17-79]
- Children's Discovery Institute of Washington University
- St. Louis Children's Hospital
Necrotizing enterocolitis (NEC) remains a leading cause of preterm infant mortality. NEC is multifactorial and believed a consequence of intestinal immaturity, microbial dysbiosis, and an exuberant inflammatory response. Over the past decade, exaggerated Toll-like receptor 4 (TLR4) activity in the immature intestine of preterm neonates emerged as an inciting event preceding NEC. Increased TLR4 signaling in epithelial cells results in the initiation of an uncontrolled immune response and destruction of the mucosal barrier. This article discusses the state of the science of the molecular mechanisms involved in TLR4-mediated inflammation during NEC and the development of new therapeutic strategies to prevent NEC.
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