期刊
CLINICAL TRANSPLANTATION
卷 33, 期 2, 页码 -出版社
WILEY
DOI: 10.1111/ctr.13461
关键词
atrial fibrillation; diastolic dysfunction; donor characteristics; heart transplantation
Background Current guidelines recommend against the use of hearts from donors that abuse alcohol. We explored the effect of donor alcohol abuse (AA) on cardiac allograft function and outcomes in heart transplant (HTx) recipients. Methods Overall, 370 HTx recipients were divided into two groups: (a) the alcoholic donor group (AD, n = 58) and (b) the non-alcoholic donor group (NAD, n = 312). Results Recipients in the AD group had a slower heart rate (86 +/- 13 vs 93 +/- 13, P = 0.004) and an increased incidence of early atrial fibrillation (AF) (30% vs 11%, P = 0.003). Echocardiographic left ventricular mass was higher among alcoholic donors (171.7 +/- 66.7 vs 151.6 +/- 54.7, P = 0.02). This difference remained present 1 year following HTx (185 +/- 43 vs 166 +/- 42, P = 0.007). E/E ' was higher in the AD group (9.5 +/- 3.9 vs 8.4 +/- 2.9, P = 0.04) and a larger number of AD recipients had a ventilatory equivalent for VCO2 > 34 (50% vs 31%, P = 0.04) on cardiopulmonary exercise test. There was no significant difference in rejection, cardiac allograft vasculopathy (CAV), or survival between the groups. Conclusions Our data suggest that donor AA does not impact rejection, CAV, or intermediate-term survival, but may cause increased incidence of post-HTx AF and impaired cardiac allograft diastolic function.
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