期刊
CLINICAL SCIENCE
卷 132, 期 23, 页码 2509-2518出版社
PORTLAND PRESS LTD
DOI: 10.1042/CS20180690
关键词
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资金
- National Institutes of Health/National Institute on Aging [R21 AG051077, R01 AG054523]
- American Heart Association [15MCPRP25680019]
- National Iinstitutes of Health/National Institute of Neurological Disorders and Stroke [NS075107]
- Wake Forest School of Medicine Pepper Center [P30 AG21332]
- Wake Forest School of Medicine Alzheimer's Disease Research Center [P30 AG049638]
Blood-based bioenergetic profiling has promising applications as a minimally invasive biomarker of systemic bioenergetic capacity. In the present study, we examined peripheral blood mononuclear cell (PBMC) mitochondrial function and brain morphology in a cohort of African Americans with long-standing Type 2 diabetes. Key parameters of PBMC respiration were correlated with white matter, gray matter, and total intracranial volumes. Our analyses indicate that these relationships are primarily driven by the relationship of systemic bioenergetic capacity with total intracranial volume, suggesting that systemic differences in mitochondria! function may play a role in overall brain morphology.
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