期刊
CLINICAL NEUROPHYSIOLOGY
卷 130, 期 1, 页码 180-188出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2018.10.007
关键词
Multiple sclerosis; Remyelination; Visual function; Multifocal visual evoked potential; Contrast sensitivity; Optic neuritis
资金
- NIH [P30 EY07551]
- Fight for Sight Summer Student Fellowship 2011
- Minnie Flaura Turner Memorial Fund for Impaired Vision Research 2012
Objective: To examine the relationship between optical coherence tomography (OCT) macular ganglion cell-inner plexiform layer thickness (GCIPLT), peripapillary retinal nerve fiber layer thickness (RNFLT) and visual function in relapsing-remitting multiple sclerosis (RRMS). Methods: Cirrus OCT, VERIS 60-sector multifocal visual evoked potential (mfVEP) and Pelli-Robson contrast sensitivity (CS) were obtained for 53 eyes with last optic neuritis (ON) > 6 months and 105 non-ON eyes in 90 patients. One eye (43 ON, 73 non-ON) was used for correlations when both had the same history. Global (G, 60 sectors) and central 5.6 degrees (C, 24 sectors) mfVEP amplitude and latency were calculated as mean logSNR and median latency. Results: Eyes showing abnormal mfVEP (amplitude or latency) vs OCT (GCIPLT or RNFLT) was 77% vs 69% (p = 0.33) in ON, 45% vs 22% (p < 0.0005) in non-ON. In ON and non-ON, mfVEP measures and CS correlated with GCIPLT and RNFLT (r = -0.24 to 0.78, p = 0.03-0.0001). In ON, mfVEP amplitude (C,G) correlated better with GCIPLT (r = 0.78, 0.76) than RNFLT (r = 0.43, 0.58; p < 0.001, 0.01). Conclusions: MfVEP measures and CS correlated well with GCIPLT and RNFLT in ON and non-ON. MfVEP amplitudes were more highly correlated with GCIPLT than RNFLT in ON. MfVEP detected significantly more defects than OCT in non-ON. Significance: GCIPLT, mfVEP and CS provide useful measures of optic nerve integrity in RRMS. (C) 2018 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
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