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The role of galectin-3 in heart failure and cardiovascular disease

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WILEY
DOI: 10.1111/1440-1681.13048

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aldosterone; angiotenin II; cardiovascular disease; fibrosis; galectin-3

资金

  1. Chinese National Natural Science Foundation [81300248, 81570358]

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Galectin-3, a -galactoside-binding lectin, is a new important player in the progression of heart failure (HF) and is also linked to poor outcome in patients with cardiovascular disease. Genetic or pharmacological inhibition of galectin-3 slows down the progression of myocardial inflammation, reduces collagen production, attenuates cardiac remodelling, and ameliorates cardiac function. In this review, we summarize recent progress in research on galectin-3 as a regulatory molecule involved in cardiovascular fibrosis in HF and its potential role in the diagnosis, risk assessment and treatment of cardiovascular diseases.

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