期刊
WORLD JOURNAL OF STEM CELLS
卷 7, 期 1, 页码 116-125出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4252/wjsc.v7.i1.116
关键词
Induced pluripotent stem cells; Cell reprogramming
资金
- Support Program to break the bottlenecks at R&D Systems for accelerating the practical use of Health Research Outcome
- Highway Program for the Realization of Regenerative Medicine
- Health Labour Sciences Research Grant
Reprograming somatic cells using exogenetic gene expression represents a groundbreaking step in regenerative medicine. Induced pluripotent stem cells (iPSCs) are expected to yield novel therapies with the potential to solve many issues involving incurable diseases. In particular, applying iPSCs clinically holds the promise of addressing the problems of immune rejection and ethics that have hampered the clinical applications of embryonic stem cells. However, as iPSC research has progressed, new problems have emerged that need to be solved before the routine clinical application of iPSCs can become established. In this review, we discuss the current technologies and future problems of human iPSC generation methods for clinical use.
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