期刊
CLIMACTERIC
卷 22, 期 4, 页码 361-369出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/13697137.2018.1547698
关键词
Hearing loss; menopause; estrogen; prestin; MYO7A
资金
- Excellent Youth Foundation of Peking University Ninth School of Clinical Medicine [2016-q26]
- Beijing Municipal Administration [PX2018031]
- National Natural Science Foundation of China [81571399]
Objective: This study aimed to test the hearing function and to investigate the effect of estrogen on prestin and MYO7A expression in hair cells of the cochlea in ovariectomized rats.Study design: We compared the hearing function systematically in normal female Sprague-Dawley rats and in ovariectomized rats with or without exogenous -estradiol administration by auditory brainstem response measurements and distortion product otoacoustic emissions. In addition, a correlation analysis between the functional parameters and cochlear histology was carried out.Results: There was a significant auditory threshold shift in the high-frequency range in the ovariectomized rats. Prestin and MYO7A expression was lowered in the cochlea of ovariectomized rats. These effects could be recovered by subcutaneous administration of -estradiol.Conclusion: Low estrogen levels may lead to reduced expression of prestin and MYO7A in cochlea, leading to a menopause-related hearing loss.
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