期刊
FRONTIERS IN ONCOLOGY
卷 5, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2015.00053
关键词
gene expression; single cell; qPCR; RNA sequencing; FISH
类别
资金
- Israel Science Foundation (ICORE) [1902/12, 1634/13, 2017/13]
- Israel Cancer Association [20140071]
Traditionally, gene expression measurements were performed on bulk samples containing populations of thousands of cells. Recent advances in genomic technology have made it possible to measure gene expression in hundreds of individual cells at a time. As a result, cellular properties that were previously masked in bulk measurements can now be observed directly. In this review, we will survey emerging technologies for single cell transcriptomics, and describe how they are used to study complex disease such as cancer, as well as other biological phenomena such as tissue regeneration, embryonic development, and immune response.
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