期刊
CHROMOSOME RESEARCH
卷 27, 期 1-2, 页码 31-40出版社
SPRINGER
DOI: 10.1007/s10577-018-09603-9
关键词
RNA polymerase I (RPI; PolI; Polr1); RPI associated factor RRN3 (TIF-IA or TIF1A); Upstream binding factor (UBF; UBTF); Ribosome biogenesis; Ribosomal RNA (rRNA) genes; Ribosomal DNA (rDNA); Active rDNA chromatin; Silent rDNA chromatin
资金
- Canadian Institutes of Health Research (CIHR) [MOP12205/PJT153266]
- National Science and Engineering Council (NSERC) of Canada
- Fonds de Recherche du Quebec-Sante (FRQS)
The rRNA genes of mouse and human encode the three major RNAs of the ribosome and as such are essential for growth and development. These genes are present in high copy numbers and arranged as direct repeats at the Nucleolar Organizer Regions on multiple chromosomes. Not all the rRNA genes are transcriptionally active, but the molecular mechanisms that determine activity are complex and still poorly understood. Recent studies applying a novel Deconvolution Chromatin Immunoprecipitation (DChIP-Seq) technique in conjunction with conditional gene inactivation provide new insights into the structure of the active rRNA genes and question previous assumptions on the role of chromatin and histone modifications. We suggest an alternative model for the active rRNA gene chromatin and discuss how this structure is determined and maintained.
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