4.7 Article

Self-assembled nanozyme complexes with enhanced cascade activity and high stability for colorimetric detection of glucose

期刊

CHINESE CHEMICAL LETTERS
卷 30, 期 5, 页码 1009-1012

出版社

ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2018.12.021

关键词

Nanozyme; CeO2; Cascade; Catalyze; Stability

资金

  1. National Natural Science Foundation of China [21675120]
  2. National Key R&D Program of China [2017YFA0208000]
  3. Ten Thousand Talents Program for Young Talents

向作者/读者索取更多资源

Construction of multi-enzyme complexes not only can help expand the understanding of biological mechanisms, but also holds great promise in biosynthesis, biosensing and biomedicine. Herein, a hybrid multi-enzyme system, CeO2/glucose oxidase (GOx) nanocomplex was developed via self-assembly and exhibited excellent catalytic activity toward cascade reactions. Compared to mixed GOx and CeO2, the nanocomplexes displayed enhanced efficiency, mainly attributed to the minimal diffusion of intermediate in the nanocomplexes system. Moreover, the nanocomplexes exhibited outstanding long-term stability and excellent recyclability. Benefiting from these merits, a highly sensitive and selective biosensor for colorimetric detection of glucose was constructed based on CeO2/GOx nanocomplexes. Such a self-assembled nanozyme complex offers a simple and efficient example to build spatially confined multi-enzyme systems to potentiate their applications in energy conversion, detoxification and bioanalysis (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

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