期刊
CHIMIA
卷 72, 期 12, 页码 888-891出版社
SWISS CHEMICAL SOC
DOI: 10.2533/chimia.2018.888
关键词
Asymmetric reaction; Benzofuran; Cyclization; Domino reaction; Rhodium
资金
- JSPS KAKENHI [23750115, 25410054, 16K05783]
- Kurata Memorial Hitachi Science and Technology Foundation
- Sumitomo Foundation
- Grants-in-Aid for Scientific Research [23750115, 16K05783] Funding Source: KAKEN
A rhodium(I)-catalyzed domino-type sequential 5-endo/5-exo cyclization reaction of [(2-acylphenyl) ethynyl]phenols produces indene/benzofuran-fused alcohols. A moderate asymmetric induction is observed when chiral diphosphine ligands are used for rhodium. Indene/indole-fused compounds are synthesized by a similar reaction of [(2-acetylphenyl)ethynyl]anilines. The domino-type 5-endo/5-exo cyclization reaction is extended to substrates having two phenolic hydroxy groups. A linearly-fused array of five- and six-membered rings is constructed. Fused and linked benzofurans possessing 2-cyanoethyl side chains are also synthesized through sequential formation of C-O and C-C bonds.
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